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dc.contributor.authorDzięgielewski, Marek
dc.contributor.authorHejmanowska, Joanna
dc.contributor.authorAlbrecht, Łukasz
dc.date.accessioned2016-01-29T08:41:07Z
dc.date.available2016-01-29T08:41:07Z
dc.date.issued2014
dc.identifier.citationSynthesis, Vol. 46 no.23 , s. 3233-3238
dc.identifier.urihttp://hdl.handle.net/11652/1005
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/html/10.1055/s-0034-1378997
dc.description.abstractQuaternary amino acids containing a geminal bisphosphonate moiety have been synthesized for the first time. The developed two-step reaction sequence utilizes the Michael addition of α-substituted azlactones to a vinylidene bisphosphonate as the key step. The reaction proceeds under catalytic conditions with excellent regioselectivity. Subsequent, acid-mediated azlactone ring opening affords the target quaternary amino acids with good overall yields. Attempts to develop an enantioselective version of the synthetic strategy are described.en_EN
dc.language.isoenen_EN
dc.relation.ispartofseriesSynthesis, Vol. 46 no.23, 2014en_EN
dc.subjectazlactonesen_EN
dc.subjectquaternary amino acidsen_EN
dc.subjectgeminal bisphosphonatesen_EN
dc.subjectMichael additionen_EN
dc.subjectbiologically relevant moleculesen_EN
dc.titleA Convenient Approach to a Novel Group of Quaternary Amino Acids Containing­ a Geminal Bisphosphonate Moietyen_EN
dc.typeArtykułpl_PL
dc.typeArticleen_EN


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