A Convenient Approach to a Novel Group of Quaternary Amino Acids Containing a Geminal Bisphosphonate Moiety
| dc.contributor.author | Dzięgielewski, Marek | |
| dc.contributor.author | Hejmanowska, Joanna | |
| dc.contributor.author | Albrecht, Łukasz | |
| dc.date.accessioned | 2016-01-29T08:41:07Z | |
| dc.date.available | 2016-01-29T08:41:07Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Quaternary amino acids containing a geminal bisphosphonate moiety have been synthesized for the first time. The developed two-step reaction sequence utilizes the Michael addition of α-substituted azlactones to a vinylidene bisphosphonate as the key step. The reaction proceeds under catalytic conditions with excellent regioselectivity. Subsequent, acid-mediated azlactone ring opening affords the target quaternary amino acids with good overall yields. Attempts to develop an enantioselective version of the synthetic strategy are described. | en_EN |
| dc.identifier.citation | Synthesis, Vol. 46 no.23 , s. 3233-3238 | |
| dc.identifier.uri | http://hdl.handle.net/11652/1005 | |
| dc.identifier.uri | https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0034-1378997 | |
| dc.language.iso | en | en_EN |
| dc.relation.ispartofseries | Synthesis, Vol. 46 no.23, 2014 | en_EN |
| dc.subject | azlactones | en_EN |
| dc.subject | quaternary amino acids | en_EN |
| dc.subject | geminal bisphosphonates | en_EN |
| dc.subject | Michael addition | en_EN |
| dc.subject | biologically relevant molecules | en_EN |
| dc.title | A Convenient Approach to a Novel Group of Quaternary Amino Acids Containing a Geminal Bisphosphonate Moiety | en_EN |
| dc.type | Artykuł | pl_PL |
| dc.type | Article | en_EN |