Oligo(ethylene glycol) methyl ether methacrylate based hydrogel with intrinsic antibacterial activity against Pseudomonas aeruginosa as a model of a major wound infecting human pathogen
Ładowanie...
Data
2024
Tytuł czasopisma
ISSN czasopisma
Tytuł tomu
Wydawca
Abstrakt
Wound dressings represent the first important defense line against potentially life-threatening infections. Successful materials should unify efficiency, simplicity of production with the ease of application. Cationic polymers based on quaternary ammonium salt moieties along the polymer chain promise high efficacy against growth of relevant pathogens including drug-resistant strains. We present a novel and easy-to-handle wound dressing material based on the well-defined copolymers of oligo(ethylene glycol) methyl ether methacrylate (OEGMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA), using quaternization with 1,6-dibromohexane for hydrogel formation. The material obtained from this robust approach was perfectly biocompatible with human dermal fibroblasts and revealed an auspicious degree of intrinsic antibacterial activity against P. aeruginosa as a model pathogen for hospital-acquired infections. Formation of bacterial biofilms was prevented in early- and late-stages and even planktonic cells were killed upon gel contact. The rheological properties of the hydrogel materials were comprehensively characterized in both dry and swollen states. Excellent biological performance and appropriate viscoelastic properties qualify the hydrogels from our production approach as truly promising novel wound dressing materials with long-lasting and contact-active bactericidal activities. We believe that this charmingly simple procedure and the mechanical properties of the hydrogel may open new avenues towards cost-effective next-generation first-line wound-care materials.
Opis
The raw/processed data required to reproduce these findings cannot
be shared at this time as the data also forms part of an ongoing study.
The financial support from National Science Centre, Poland is gratefully acknowledged (Grant UMO-2020/39/I/ST5/02108). For the purpose of Open Access, the authors have applied a CC-BY public copyright license to any Author Accepted Manuscript (AAM) version arising from this submission. This work was also supported by grant from the German Research Society (DFG) project 465229237.
The financial support from National Science Centre, Poland is gratefully acknowledged (Grant UMO-2020/39/I/ST5/02108). For the purpose of Open Access, the authors have applied a CC-BY public copyright license to any Author Accepted Manuscript (AAM) version arising from this submission. This work was also supported by grant from the German Research Society (DFG) project 465229237.
Słowa kluczowe
Biocidal surfaces, Wound healing, Quaternization, Wound dressing, Gels, P. aeruginosa
Cytowanie
Çetinkaya, A.; Kissmann, A.; Lipinska, M.; Trzaskowska, M.; Duniec, J.; Katariya, H.; Slouf, M.; Herberger, T.; Weil, T.; Przekora, A.; Rosenau, F.; Pietrasik, J. Oligo(ethylene glycol) methyl ether methacrylate based hydrogel with intrinsic antibacterial activity against Pseudomonas aeruginosa as a model of a major wound infecting human pathogen. European Polymer Journal 205 (2024) 112758. https://doi.org/10.1016/j.eurpolymj.2024.112758