Artykuły (WBiNoŻ)

Stały URI dla kolekcjihttp://hdl.handle.net/11652/147

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2012 - 201922020 - 20231

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Autorsearch.filters.applied.operator.equals: search.filters.author.Gałęcki, KrystianMa przypisane plikisearch.filters.applied.operator.equals: Tak

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Teraz wyświetlane 1 - 3 z 3
  • Pozycja
    A comparative analysis of European and British cosmetic products legislation
    (Wydawnictwo Politechniki Łódzkiej, 2023) Kramarczuk, Patrycja; Gałęcki, Krystian
    Due to the withdrawal of the United Kingdom of Great Britain and Northern Ireland from the European Union (EU), cosmetic products made available in this country are no longer subject to European legislation, but to British cosmetics law. The exit process (Brexit) was a rather chaotic event with not fully known consequences. The legal changes brought about by Brexit are difficult to understand for many cosmetic companies. Therefore, the aim of this work was to compare and demonstrate the legal differences between European and British cosmetic law, resulting from the withdrawal of the United Kingdom from the EU. The main differences concern the issues related to the responsible person, notification, documentation and labelling of the cosmetic product.
  • Pozycja
    Experimental and theoretical investigation of drotaverine binding to bovine serum albumin
    (Wydawnictwo Politechniki Łódzkiej, 2013) Gałęcki, Krystian; Courtade, Gaston; McFall, Aisling; Prieschl, Teixeira Renata; Grgic, Maja; Esteve-Sistere, Marta; Maglemose, Westphalen Rikke; Kowalska-Baron, Agnieszka
    This study was motivated by the need to provide more insight into the possible mechanism of the intermolecular interactions between antispasmodic drug drotaverine and one of the serum albumins (BSA), with the aim to indicate the most probable sites of these interactions. For this purpose both experimental (spectrofluorometric titration at various temperatures) and theoretical (molecular mechanics) methods have been applied. The obtained results clearly showed that drotaverine quenched BSA fluorescence, and the most probable mechanism is static quenching. The negative value of the theoretically predicted binding free Gibbs energy (-23.8 kJ/mol) confirmed the existence of the intermolecular interactions involving drotaverine and one tryptophan within BSA protein and was well agreed with the experimentally determined value of -25.2 kJ/mol.
  • Pozycja
    Binding of harmane to human and bovine serum albumin: fluorescence and phosphorescence study
    (Wydawnictwo Politechniki Łódzkiej, 2012) Gałęcki, Krystian; Despotović, Biljana; Galloway, Celine; Ioannidis, Angelos-Gerasimos; Janani, Tahereh; Nakamura, Yuki; Oluyinka, Grace
    The binding of harmane with human serum albumin (HSA) and bovine serum albumin (BSA) were studied by fluorescence and phosphorescence spectroscopic methods. Quenching of fluorescence of serum albumins by harmane was found to be a static quenching process. The equilibrium constant (K) of complex formation was found to be equal to (5.16±0.28)x104M-1and (4.32±0.30)x104M-1for HSA and BSA, respectively. It was found that the interactions of harmane with HSA and BSA were also in the excited triplet state. The determined bimolecular constant or triplet state quenching (kqT)of the proteins studied by harmane was (1.15± 0.10)x107M-1s-1and (2.88±0.22)x107M-1s-1for HSA and BSA, respectively. Based on the similar value of K and kqTfor HSA and BSA, a possible suggestion is that, most probably, the binding site of harmane is located in the drug site 1 in the subdomain IIa.