Artykuły (WBiNoŻ)

Stały URI dla kolekcjihttp://hdl.handle.net/11652/147

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20081

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Autorsearch.filters.applied.operator.equals: search.filters.author.Casares, Daniela

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  • Pozycja
    The study of interactions between Diclofenac and Bovine Serum Albumin (BSA)
    (Wydawnictwo Politechniki Łódzkiej, 2008) Jabłońska, Joanna; Casares, Daniela; Funfer, Johanna; Habenschuss, Thomas; Jimenez, Gabriela; Klemm, Anna Lena; Machado, Antonio Magela Junior; Miloshevska, Sandra; Papista, Ivana; Urlich-Lynge, Sofie Louise
    Investigation of the interactions between diclofenac and BSA was performed using UV-Vis absorption and fluorescence methods. There was a quenching effect found between these two molecules in the fluorescence measurement methods; steady-state and time-resolved. The fluorescence decay time enables to determine the quenching mechanism and thus conclude that the complex is formed in ground-state but also collisional quenching - when the excited-state fluorophore of BSA is deactivated - occurs. Computer modeling was applied to observe and optimize the formation of the complex between N-acetyl-L-tryptophamide and diclofenac.