Artykuły (WCh)

Stały URI dla kolekcjihttp://hdl.handle.net/11652/155

Przeglądaj

Filtry

20142

Ustawienia

Autorsearch.filters.applied.operator.equals: search.filters.author.Pawełczyk, Jakub

collection.search.results.head

Teraz wyświetlane 1 - 2 z 2
  • Pozycja
    Triazole-Based Compound as a Candidate To Develop Novel Medicines To Treat Toxoplasmosis
    (2014) Dzitko, Katarzyna; Paneth, Agata; Plech, Tomasz; Pawełczyk, Jakub; Węglińska, Lidia; Paneth, Piotr
    This article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined 50% inhibitory concentration (IC50) at least 30 times better than that of the known chemotherapeutic agent sulfadiazine. Purine nucleoside phosphorylase was defined as the probable target for anti-Toxoplasma activity of the tested compound. These results provide the foundation for future work to develop a new class of medicines to better treat toxoplasmosis.
  • Pozycja
    1,4-disubstituted thiosemicarbazide derivatives are potent inhibitors of toxoplasma gondii proliferation.
    (2014) Dzitko, Katarzyna; Paneth, Agata; Plech, Tomasz; Pawełczyk, Jakub; Stączek, Paweł; Stefańska, Joanna; Paneth, Piotr
    A series of 4-arylthiosemicarbazides substituted at the N1 position with a 5-membered heteroaryl ring was synthesized and evaluated in vitro for T. gondii inhibition proliferation and host cell cytotoxicity. At non-toxic concentrations for the host cells all studied compounds displayed excellent anti-parasitic effects when compared to sulfadiazine, indicating a high selectivity of their anti-T. gondii activity. The differences in bioactivity investigated by DFT calculations suggest that the inhibitory activity of 4-arylthiosemicarbazides towards T. gondii proliferation is connected with the electronic structure of the molecule. Further, these compounds were tested as potential antibacterial agents. No growth-inhibiting effect on any of the test microorganisms was observed for all the compounds, even at high concentrations.