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Stały URI dla kolekcjihttp://hdl.handle.net/11652/155

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20141

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Autorsearch.filters.applied.operator.equals: search.filters.author.Dzięgielewski, MarekTematsearch.filters.applied.operator.equals: search.filters.subject.biologically relevant molecules

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  • Pozycja
    A Convenient Approach to a Novel Group of Quaternary Amino Acids Containing­ a Geminal Bisphosphonate Moiety
    (2014) Dzięgielewski, Marek; Hejmanowska, Joanna; Albrecht, Łukasz
    Quaternary amino acids containing a geminal bisphosphonate moiety have been synthesized for the first time. The developed two-step reaction sequence utilizes the Michael addition of α-substituted azlactones to a vinylidene bisphosphonate as the key step. The reaction proceeds under catalytic conditions with excellent regioselectivity. Subsequent, acid-mediated azlactone ring opening affords the target quaternary amino acids with good overall yields. Attempts to develop an enantioselective version of the synthetic strategy are described.