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  • Pozycja
    New strategies targeting the unfolded protein response (PERK signaling) for cancer treatment
    (Wydawnictwo Politechniki Łodzkiej, 2018) Pytel, D.; Szulc, Z. M.; Mucha, B.; Majsterek, I.; Diehl, J. A.
    "Cancer cells exhibit increased metabolism and proliferation rates. The UPR (Unfolded Protein Response) has garnered attention as a signaling network utilized by cancer cells that contributes to a number of oncogenic processes. The UPR activates three signal transducers (ATF6, IRE1 and PERK); of these the kinase PERK can both potentiate cell survival during moderate stress and provide a mechanism for recovery if cells do not commit to an apoptotic fate. Thus, dissection of the molecular mechanisms whereby PERK signaling influences."