Bacterial inhibition via carboxymethyl cellulose-containing electrospun mats loaded with nisin z peptide for potential chronic wound care

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dc.contributor.authorTavares, Tânia D.
dc.contributor.authorSilva, Carla
dc.contributor.authorAntunes, Joana C.
dc.contributor.authorFelgueiras, Helena P.
dc.date.accessioned2022-11-23T08:51:01Z
dc.date.available2022-11-23T08:51:01Z
dc.date.issued2022
dc.description.abstractNisin Z is an amphipathic peptide with a significant antibacterial activity against Gram-positive bacteria and low toxicity in humans. Here, we report the production of nanofibrous mats by co-electrospinning of the peptide with carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) polymers for prospective wound dressing applications. The mats were studied against four of the most common bacteria found in chronic wounds. The evaluation of bacteria membrane permeability and the minimum inhibitory concentration (MIC) showed that chelating agent ethylenediaminetetraacetic acid (EDTA) can expand the activity of Nisin Z against Gram-negative bacteria. PVA (10 wt%)/CMC (3 wt%) electrospinning nanofibers were successfully produced at a 70/30 % (v/v) polymer ratio. The addition of Nisin Z to the polymer solutions did not alter the properties of the fibers.en_EN
dc.identifier.citationTavares T.D., Silva C., Antunes J.C., Felgueiras H.P., Bacterial inhibition via carboxymethyl cellulose-containing electrospun mats loaded with nisin z peptide for potential chronic wound care. W: AUTEX 2022 : 21st World Textile Conference AUTEX 2022 - AUTEX Conference Proceedings, Lodz University of Technology Press, Lodz 2022, s. 211-215, ISBN 978-83-66741-75-1, doi: 10.34658/9788366741751.44.
dc.identifier.doi10.34658/9788366741751.44
dc.identifier.isbn978-83-66741-75-1
dc.identifier.urihttp://hdl.handle.net/11652/4477
dc.identifier.urihttps://doi.org/10.34658/9788366741751.44
dc.language.isoenen_EN
dc.page.numbers. 211-215
dc.publisherWydawnictwo Politechniki Łódzkiejpl_PL
dc.publisherLodz University of Technology Pressen_EN
dc.relation.ispartofAUTEX 2022 : 21st World Textile Conference AUTEX 2022 - AUTEX Conference Proceedings, Lodz University of Technology Press, Lodz 2022, ISBN 978-83-66741-75-1, doi: 10.34658/9788366741751
dc.rightsDla wszystkich w zakresie dozwolonego użytkupl_PL
dc.rightsFair use conditionen_EN
dc.rights.licenseLicencja PŁpl_PL
dc.rights.licenseLUT Licenseen_EN
dc.subjectantimicrobial peptidesen_EN
dc.subjectpolymersen_EN
dc.subjectelectrospun nanofibersen_EN
dc.subjectpeptydy przeciwdrobnoustrojowepl_PL
dc.subjectpolimerypl_PL
dc.subjectnanowłókna elektroprzędzonepl_PL
dc.titleBacterial inhibition via carboxymethyl cellulose-containing electrospun mats loaded with nisin z peptide for potential chronic wound careen_EN
dc.typeartykuł - konferencjapl_PL
dc.typearticle - conferenceen_EN

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