Extremophilic and modified aminotransferases as a versatile tool for the synthesis of optically pure building blocks for pharmaceutical industry

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dc.contributor.authorSzmejda, Klaudia
dc.contributor.authorFlorczak, Tomasz
dc.contributor.authorJodłowska, Iga
dc.contributor.authorTurkiewicz, Marianna
dc.date.accessioned2017-09-04T07:03:10Z
dc.date.available2017-09-04T07:03:10Z
dc.date.issued2017
dc.description.abstractConsiderable progress has been made in the past few years with industrial use of essential key intermediates for chemical and pharmaceutical industry. The increasing demand for obtaining chiral drugs in enantiomerically pure form makes it necessary to search for novel biocatalysts useful in the synthesis of amino acids, chiral amines, amino sugars and alcohols. According to the reaction mechanism, aminotransferases (ATs) have useful applications because of their capability of transfer of an amino group from a donor substrate to an acceptor, thus resulting in the synthesis of a wide variety of building blocks. This article reviews current biocatalytic approaches using microbial ATs in the synthesis of optically active products. Focus is also put on the engineering of ATs and their limitations in the industrial applications. Moreover this review covers biocatalytic approaches using ATs isolated from extreme environments.pl_PL
dc.formatapplication/pdf
dc.identifier.citationBiotechnology and Food Science 2017, Vol.81 No.1, p.23-34pl_PL
dc.identifier.issn2084-0136
dc.identifier.otherBrak expID
dc.identifier.urihttp://www.bfs.p.lodz.pl
dc.language.isoplpl_PL
dc.publisherLodz University of Technology Pressen_EN
dc.publisherWydawnictwo Politechniki Łódzkiejpl_PL
dc.relation.ispartofseriesBiotechnology and Food Science;en_EN
dc.relation.ispartofseriesZeszyty Naukowe Politechniki Łódzkiej;pl_PL
dc.subjectAminotransferasesen_EN
dc.subjectBiotransformationsen_EN
dc.subjectunnatural amino acidsen_EN
dc.subjectAminotransferazypl_PL
dc.subjectbiokonwersjapl_PL
dc.titleExtremophilic and modified aminotransferases as a versatile tool for the synthesis of optically pure building blocks for pharmaceutical industryen_EN
dc.typeArtykułpl_PL
dc.typeArticleen_EN

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