Antybakteryjne i atrombogenne włókna poliestrowe

dc.contributor.advisorBocheńska, Jadwiga
dc.contributor.authorKaraszewska, Agnieszka
dc.contributor.reviewerLipp-Symonowicz, Barbara
dc.contributor.reviewerJaworski, Adam
dc.date.accessioned2021-06-24T07:50:17Z
dc.date.available2021-06-24T07:50:17Z
dc.date.issued2008
dc.description.abstractOpracowano metodę otrzymywania implantów medycznych z poli(tereftalanu etylenowego) PET o właściwościach antybakteryjnych i atrombogennych, na które są wrażliwe bakterie Gram+ i Gram-. Metoda polegała na dwustopniowej modyfikacji implantów, w której w znikomych ilościach powstaje produkt uboczny, zatem metoda ta jest praktycznie bezodpadowa. Przeprowadzono wstępne badania (in vivo), działania drażniącego oraz zbadano właściwości atrombogenne modyfikowanych wyrobów. Stwierdzono, że nici chirurgiczne PET oraz protezy naczyniowe, zawierające w swej budowie biocyd przyłączony wiązaniem chemicznym, są w dużym stopniu aktywne w stosunku do bakterii Gram+ i Gram-.pl_PL
dc.description.abstractIn order to provide polyester with antibacterial and atrombogenic properties, a two-stage modification of polyester yarn, surgical threads and vascular prothesis was carried out. Modification was based on introducing macromolecules into the polymer of carboxylic group through grafting them with PAA or PMA - I stage. In the second stage of modification, the grafted products were imbued with biocide solution from amiglicozyde group (Amikacin), which are derivatives of penicillin (Amoxycylline) and silver ions derived from non-organie salts - ( each biocide separately). A method of modification of surgical threads add knitted vascular prothesis was established, where only slight amount of by-product is created, thus the method is virtually waste-free. Throughout the simulation tests, kinetics of biocide release to water and an appropriate buffer or physiological salt from modified products was tested, assuming that any release of the drug under the influence of tissue liquids creates a possibility of inhibiting the growth of microorganisms, theref ore also creating a possibility of preventing post-operation infections. During the in vitro tests, antibacterial character of modified products was established against Gram+ and Gram- bacteria, which are typical for the hospital conditions. There were also some introductory (in vivo) tests of irritating action carried out and additionally, atrombogenic properties of modified fibres were tested. It was stated that surgical PET threads that include antibiotic in their structure are active on a wide scale towards Gram+ and Gram- bacteria. Antibiotics or Ag+ released from surgical threads are easily absorbed in tissue environment, making the wound heal without exudations or inflammations. There were also the following measurements tak.en: electrokinetic potential, water permeability and hydrophilic character of the modified fibres of vascular prothesis.en_EN
dc.identifier.citationKaraszewska A., Antybakteryjne i atrombogenne włókna poliestrowe. W: Zeszyty Naukowe Politechniki Łódzkiej. Włókiennictwo, Vol. 64, No. 1013, Wydawnictwo Politechniki Łódzkiej, Łódź 2008, s. 59-71, ISSN 0076-0331, doi: 10.34658/tex.2008.64.59-71.
dc.identifier.doihttps://doi.org/10.34658/tex.2008.64.59-71
dc.identifier.doi10.34658/tex.2008.64.59-71
dc.identifier.issn0076-0331
dc.identifier.urihttp://hdl.handle.net/11652/3655
dc.identifier.urihttps://doi.org/10.34658/tex.2008.64.59-71
dc.language.isoplpl_PL
dc.page.numbers. 59-71
dc.publisherWydawnictwo Politechniki Łódzkiejpl_PL
dc.publisherLodz University of Technology Pressen_EN
dc.relation.ispartofZeszyty Naukowe Politechniki Łódzkiej. Włókiennictwo, Vol. 64, No. 1013, Wydawnictwo Politechniki Łódzkiej, Łódź 2008, ISSN 0076-0331.
dc.rightsFair use conditionen_EN
dc.rightsDla wszystkich w zakresie dozwolonego użytkupl_PL
dc.rights.licenseLUT Licenceen_EN
dc.rights.licenseLicencja PŁpl_PL
dc.subjectwłókno poliestrowepl_PL
dc.subjectantybakteryjne włókno poliestrowepl_PL
dc.subjectwłókno poliestrowe atrombogennepl_PL
dc.subjectimplanty medycznepl_PL
dc.subjectbiocydpl_PL
dc.subjectbadania in vivopl_PL
dc.subjectpolyester fibreen_EN
dc.subjectantibacterial polyester fibreen_EN
dc.subjectatrombogenic polyester fibreen_EN
dc.subjectmedical implantsen_EN
dc.subjectbiocideen_EN
dc.subjectin vivo studiesen_EN
dc.titleAntybakteryjne i atrombogenne włókna poliestrowepl_PL
dc.title.alternativeAntibacterial and atrombogenic polyester fibrespl_PL
dc.typeArtykułpl_PL
dc.typeArticleen_EN

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