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dc.contributor.authorModranka, Jakub
dc.contributor.authorJakubowski, Rafał
dc.contributor.authorJanecki, Tomasz
dc.date.accessioned2016-02-09T07:58:46Z
dc.date.available2016-02-09T07:58:46Z
dc.date.issued2014
dc.identifier.citationSynlett, Vol. 25, Issue 1, pages 105-109
dc.identifier.urihttp://hdl.handle.net/11652/1151
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0033-1340071
dc.description.abstractA new, versatile method for the synthesis of, so far unknown, variously substituted 4-methylidenepyrazolidin-3-ones as potential cytotoxic agents is described. Target compounds were synthesized from the corresponding 4-diethoxyphosphorylpyrazolidin-3-ones which were used as Horner–Wadsworth–Emmons ­reagents for the olefination of formaldehyde. 4-Phosphorylpyrazolidin-3-ones were, in turn, obtained starting from the sodium salt of ethyl 2-diethoxyphosphoryl-3-hydroxy-2-propenoate, ethyl 2-acyl-2-diethoxyphosphorylacetates, or 3-methoxy-2-diethoxyphosphorylacrylate and monosubstituted or 1,2-disubstituted hydrazines.en_EN
dc.language.isoenen_EN
dc.relation.ispartofseriesSynlett, Vol. 25, Issue 1, 2014en_EN
dc.subjectalkylationen_EN
dc.subjectantitumor agentsen_EN
dc.subjectheterocyclesen_EN
dc.subjectlactamsen_EN
dc.subjectMichael additionen_EN
dc.subjectolefinationen_EN
dc.titleVersatile Synthesis of 4-Methylidenepyrazolidin-3-ones Using a Horner–Wadsworth–Emmons Approachen_EN
dc.typeArtykułpl_PL
dc.typeArticleen_EN


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