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Triazole-Based Compound as a Candidate To Develop Novel Medicines To Treat Toxoplasmosis

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Triazole_Based_Compound_Dzitko_2014.pdf (294.2Kb)
Date
2014
Author
Dzitko, Katarzyna
Paneth, Agata
Plech, Tomasz
Pawełczyk, Jakub
Węglińska, Lidia
Paneth, Piotr
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Abstract
This article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined 50% inhibitory concentration (IC50) at least 30 times better than that of the known chemotherapeutic agent sulfadiazine. Purine nucleoside phosphorylase was defined as the probable target for anti-Toxoplasma activity of the tested compound. These results provide the foundation for future work to develop a new class of medicines to better treat toxoplasmosis.
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http://hdl.handle.net/11652/1149
http://aac.asm.org/content/58/12/7583.full.pdf+html
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