Show simple item record

dc.contributor.authorAbramczyk, Halina
dc.contributor.authorBrożek-Płuska, Anna
dc.contributor.authorSurmacki, Jakub
dc.contributor.authorMusiał, Jacek
dc.contributor.authorKordek, Radzisław
dc.date.accessioned2016-02-05T07:42:12Z
dc.date.available2016-02-05T07:42:12Z
dc.date.issued2014
dc.identifier.citationAnalyst, Vol. 139, Issue 21, pages 5547-5559
dc.identifier.issn0003-2654
dc.identifier.otherISSN (online) 1364-5528
dc.identifier.urihttp://hdl.handle.net/11652/1104
dc.identifier.urihttp://pubs.rsc.org/en/content/articlelanding/2014/an/c4an00966e#!divAbstract
dc.description.abstractRaman microspectroscopy and confocal Raman imaging combined with confocal fluorescence were used to study the distribution and aggregation of aluminum tetrasulfonated phthalocyanine (AlPcS4) in noncancerous and cancerous breast tissues. The results demonstrate the ability of Raman spectroscopy to distinguish between noncancerous and cancerous human breast tissue and to identify differences in the distribution and aggregation of aluminum phthalocyanine, which is a potential photosensitizer in photodynamic therapy (PDT), photodynamic diagnosis (PDD) and photoimmunotherapy (PIT) of cancer. We have observed that the distribution of aluminum tetrasulfonated phthalocyanine confined in cancerous tissue is markedly different from that in noncancerous tissue. We have concluded that Raman imaging can be treated as a new and powerful technique useful in cancer photodynamic therapy, increasing our understanding of the mechanisms and efficiency of photosensitizers by better monitoring localization in cancer cells as well as the clinical assessment of the therapeutic effects of PDT and PIT.en_EN
dc.language.isoenen_EN
dc.publisherRoyal Society of Chemistryen_EN
dc.relation.ispartofseriesAnalyst, Vol. 139, Issue 21, 2014en_EN
dc.titleOncologic photodynamic diagnosis and therapy: confocal Raman/fluorescence imaging of metal phthalocyanines in human breast cancer tissue in vitroen_EN
dc.typeArtykułpl_PL
dc.typeArticleen_EN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record