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dc.contributor.authorDzitko, Katarzyna
dc.contributor.authorPaneth, Agata
dc.contributor.authorPlech, Tomasz
dc.contributor.authorPawełczyk, Jakub
dc.contributor.authorStączek, Paweł
dc.contributor.authorStefańska, Joanna
dc.contributor.authorPaneth, Piotr
dc.date.accessioned2016-01-29T07:44:51Z
dc.date.available2016-01-29T07:44:51Z
dc.date.issued2014
dc.identifier.citationMolecules 2014, 19, p. 9926-9943en_EN
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/11652/1002
dc.identifier.urihttp://www.mdpi.com/1420-3049/19/7/9926
dc.description.abstractA series of 4-arylthiosemicarbazides substituted at the N1 position with a 5-membered heteroaryl ring was synthesized and evaluated in vitro for T. gondii inhibition proliferation and host cell cytotoxicity. At non-toxic concentrations for the host cells all studied compounds displayed excellent anti-parasitic effects when compared to sulfadiazine, indicating a high selectivity of their anti-T. gondii activity. The differences in bioactivity investigated by DFT calculations suggest that the inhibitory activity of 4-arylthiosemicarbazides towards T. gondii proliferation is connected with the electronic structure of the molecule. Further, these compounds were tested as potential antibacterial agents. No growth-inhibiting effect on any of the test microorganisms was observed for all the compounds, even at high concentrations.pl_PL
dc.language.isoen_ENen_EN
dc.relation.ispartofseriesMolecules 2014, 19
dc.subjectthiosemicarbazide derivativesen_EN
dc.subjectanti-Toxoplasma gondii activityen_En
dc.subjectantibacterial activityen_EN
dc.subjectbacterial topoisomerasesen_En
dc.subjecttoxicityen_EN
dc.subjectdocking studiesen_EN
dc.subjectDFT calculationsen_EN
dc.title1,4-disubstituted thiosemicarbazide derivatives are potent inhibitors of toxoplasma gondii proliferation.en_EN
dc.typeArtykułpl_PL
dc.typeArticleen_EN


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