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Pozycja Distribution of nitrogen compounds in important sections of sugar beets(Lodz University of Technology Press, 2016) Bąk, Paulina; Antczak-Chrobot, Aneta; Wojtczak, MaciejIn literature the beet is often described as consisting of the following technologically important sections: crown, root and tail. The aim of the study was to determine the distribution of nitrogen compounds in the technologically important beet sections of untopped sugar beets with particular emphasis on the content of nitrate and nitrite. The Finezja sugar beet variety had been collected from the clamps in one of the Polish sugar factories in October during 2013/2014 campaign. The untopped sugar beets were divided into three sections: crown, root and tail. The content of total amount of nitrogen, proteinaceous nitrogen, α-amino nitrogen, the sum of the amide and ammonia nitrogen, nitrates and nitrite in these sections were determined. Although the crown of the sugar beet represented only 14.7% of it mass, this section contained on average 30% of the total quantity of α-amino acids as well as amide and ammonia nitrogen.This section contained approximately 77% of the total quantity of nitrate and 88% of nitrite. Untopped sugar beets would introduce much higher amounts of nitrogen compounds in comparison to topped raw material.Pozycja Ocena pracy przydomowej oczyszczalni ścieków(Wydawnictwo SIGMA-NOT, 2006) Borowski, Sebastian; Wojtczak, MaciejPrzeprowadzono badania efektywności oczyszczania ścieków socjalno-bytowych w osadniku gnilnym. Analizie poddawano ścieki pobierane z komór osadnika oraz studzienki rewizyjnej przed drenażem rozsączającym przydomowej oczyszczalni. Stwierdzono dużą zmienność stężeń zanieczyszczeń w kolejnych seriach pomiarowych. Wartości ChZT w I komorze osadnika wahały się w granicach 528-2153 g/m³ a zawiesiny ogólnej 186-1360 g/m³. Jednocześnie zmiany wartości średnich ładunków zanieczyszczeń miedzy I komorą, a studzienką, były niewielkie i wynosiły, 14% dla BZT5 i 26% dla ChZT. Odnotowano też 67% wzrost średniej koncentracji azotu amonowego oraz około 2-krotny wzrost stężeń fosforanów, sodu i potasu. Natomiast koncentracje metali o mniejszej rozpuszczalności, zwłaszcza żelaza i cynku, ulegały obniżeniu w toku procesu mechanicznego oczyszczania.Pozycja The relationship between plasma concentration of metoprolol and CYP2D6 genotype in patients with ischemic heart disease(Elsevier, 2014) Wojtczak, Anna; Wojtczak, Maciej; Skrętkowicz, JadwigaBackground Metoprolol is the one of the most commonly used β-blockers in the treatment of ischemic heart disease and it is extensively metabolized in the liver undergoing oxidation by CYP2D6 isoenzyme of cytochrome P450. Gene encoding the CYP2D6 enzyme is characterized by genetic polymorphism. The CYP2D6 oxidation polymorphism has a major impact on the effectiveness and safety of the treatment. The aim of the study was to evaluate the relationship between plasma concentration of metoprolol and the CYP2D6 genotype in patients with ischemic heart disease. Methods Fifty patients were interviewed and subsequently enrolled into the study. The patients received metoprolol twice daily at a dose of 50 mg. The blood samples were analyzed for two major defective alleles for CYP2D6 – CYP2D6*4 and CYP2D6*3 – by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Metoprolol concentration in plasma was determined by using the new and unique high-performance liquid chromatography (HPLC) method in the author's own modification with Corona CAD detector (Charged Aerosol Detection). Results In the test group, genotypes conditioning poor oxidation (PM) occurred in 3 patients (6%), while 47 patients (94%) had genotypes coding for extensive metabolism (EM). Patients with PM genotypes had significantly higher plasma concentrations of metoprolol than the patients with EM genotype (mean 92.25 ± SD 36.78 ng/ml vs. mean 168.22 ± SD 5.61 ng/ml, respectively). Established relationships were statistically significant (NIR test, p = 0.0009). Conclusions This study demonstrated that the CYP2D6 genotype remains a major determinant of the metoprolol plasma concentrations. The pharmacogenetic effect is likely to have consequences on both, the clinical benefit of metoprolol treatment and adverse drug reactions. The use of Corona CAD detector seems to be a very good alternative method for the determination of metoprolol concentration in plasma.Pozycja Rozwój gospodarki opartej na wiedzy – źródła finansowania postępu technologicznego i innowacyjnego przedsiębiorstw(Institute of General Food Chemistry. Faculty of Biotechnology and Food Sciences., 2007) Wojtczak, Maciej