Dzitko, KatarzynaPaneth, AgataPlech, TomaszPawełczyk, JakubWęglińska, LidiaPaneth, Piotr2016-02-092016-02-092014Antimicrobial Agents and Chemotherapy, Vol. 58, Issue 12, pages 7583-7585http://hdl.handle.net/11652/1149http://aac.asm.org/content/58/12/7583.full.pdf+htmlThis article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined 50% inhibitory concentration (IC50) at least 30 times better than that of the known chemotherapeutic agent sulfadiazine. Purine nucleoside phosphorylase was defined as the probable target for anti-Toxoplasma activity of the tested compound. These results provide the foundation for future work to develop a new class of medicines to better treat toxoplasmosis.enArtykuł