Succinic acid biosynthesis by Corynebacterium glutamicum

Uproszczony widok
dc.contributor.authorLeszczewicz, Martyna
dc.contributor.authorWalczak, Piotr
dc.date.accessioned2015-06-18T09:24:24Z
dc.date.available2015-06-18T09:24:24Z
dc.date.issued2014
dc.description.abstractSuccinic acid is one of the most desirable raw materials. Currently, it is obtained mainly by hydrogenation of maleic acid derived from the C4 petroleum fraction. Corynebacterium glutamicum is considered as a possible microbiological producer of this acid. Under oxygen deprivation conditions this bacteria secretes L-lactate, succinate and acetate. Succinic acid is an intermediate of the Krebs cycle, in order to achieve high efficiency of its biosynthesis, metabolic engineering of C. glutamicum is required. The best producers described so far are C. glutamicum R ΔldhA pCRA717 (146 g/L) and C. glutamicum BOL-3/pAN6-gap (133 g/L). Succinic acid biosynthesis can also be achieved under aerobic conditions. C. glutamicum ZX1 (pEacsAgltA) produces aerobically 21.7 g/L of succinate. Genetic engineering is also necessary to enable the use of low-cost, waste carbon source such as glycerol or starch. The paper also presents and discusses examples of modifications of bacterial cells, allowing them to use these two carbon sources.en_EN
dc.formatapplication/pdf
dc.identifier.citationBiotechnology and Food Science, 2014 Vol.78 nr 1 s.25-43pl_PL
dc.identifier.issn2084-0136
dc.identifier.other0000034711
dc.identifier.urihttp://www.bfs.p.lodz.pl
dc.language.isoenen_EN
dc.publisherWydawnictwo Politechniki Łódzkiejpl_PL
dc.publisherLodz University of Technology. Pressen_EN
dc.relation.ispartofseriesZeszyty Naukowe Politechniki Łódzkiejpl_PL
dc.relation.ispartofseriesBiotechnology and Food Scienceen_EN
dc.subjectCorynebacterium glutamicumen_EN
dc.subjectsuccinic aciden_EN
dc.subjectmetabolic engineeringen_EN
dc.subjectbakterie Corynebacteriumpl_PL
dc.subjectkwas bursztynowypl_PL
dc.subjectinżynieria metabolicznapl_PL
dc.titleSuccinic acid biosynthesis by Corynebacterium glutamicumen_EN
dc.typeArticleen_EN
dc.typeArtykułpl_PL

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