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dc.contributor.authorWujec, Monika
dc.contributor.authorKędzierska, Ewa
dc.contributor.authorKuśmierz, Edyta
dc.contributor.authorPlech, Tomasz
dc.contributor.authorWróbel, Andrzej
dc.contributor.authorPaneth, Agata
dc.contributor.authorOrzelska, Jolanta
dc.contributor.authorFidecka, Sylwia
dc.contributor.authorPaneth, Piotr
dc.date.accessioned2016-02-05T08:55:13Z
dc.date.available2016-02-05T08:55:13Z
dc.date.issued2014
dc.identifier.citationMolecules, Vol. 19, Issue 4, pages 4745-4759
dc.identifier.urihttp://hdl.handle.net/11652/1109
dc.identifier.urihttp://www.mdpi.com/1420-3049/19/4/4745
dc.description.abstractThis article describes the synthesis of six 4-aryl-(thio)semicarbazides (series a and b) linked with diphenylacetyl moiety along with their pharmacological evaluation on the central nervous system in mice and computational studies, including conformational analysis and electrostatic properties. All thiosemicarbazides (series b) were found to exhibit strong antinociceptive activity in the behavioural model. Among them, compound 1-diphenylacetyl-4-(4-methylphenyl)thiosemicarbazide 1b was found to be the most potentan algesic agent, whose activity is connected with the opioid system. For compounds from series a significant anti-serotonergic effect, especially for compound 1-diphenylacetyl-4- (4-methoxyphenyl)semicarbazide 2b was observed. The computational studies strongly support the obtained results.en_EN
dc.language.isoenen_EN
dc.relation.ispartofseriesMolecules, Vol. 19, Issue 4, 2014en_EN
dc.subject(thio)semicarbazidesen_EN
dc.subjectconformational analysisen_EN
dc.subjectelectrostatic propertiesen_EN
dc.subjectCNS activityen_EN
dc.subjectanalgesic activityen_EN
dc.subjectserotonergic activityen_EN
dc.titlePharmacological and Structure-Activity Relationship Evaluation of 4-aryl-1-Diphenylacetyl(thio)semicarbazidesen_EN
dc.typeArtykułpl_PL
dc.typeArticleen_EN


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